Can quantitative methods be used to solve the public health emergency of global concern caused by injections of instructions to make spike venom?

In a past live as an investment manager I would use linear and quadratic optimization techniques and Excel Solver to construct portfolios of assets that would either produce maximum returns for various levels of risks or produce minimum risks for various levels of returns.

“efficient” frontiers would look like this:

There are combinations of assets that lie of the efficient frontier – all other portfolios are “inefficient”. (Allowance could be made for minimum and maximum weighting in each asset to “quadratically” rather than “linearly” optimise portfolios).

Note that the point of inflection on the left (where the frontier “bends”) should be used to leverage or deleverage the portfolio and produce higher returns or lower risks or both.

These “optimisations” are based on historical returns. You grab, say 60 or 120 months of returns for each asset – work out the standard deviation, correlation and covariance matrices and then specify the objective function coefficients within solver to work out the weighting in each asset that produce the specific levels of return and risk you are interested in.

Here is a link to an explainer paper used in the forestry industry to do the same thing.

D:\Classes\For466W\TextBook\Master.PDF (washington.edu)

“So what” I see you eye-roll!

Well, maybe it is possible to define the spike venom injection problem within similar bounds.

The variables would be the different harms – to each vital organ and blood condition – from the different components of the modified mRNA injections.

Perhaps we could compile another set of variables using the solutions that have been evolving.

Perhaps we could also do the dame for interactions with existing treatments for other co-morbidities - such as obesity, diabetes, Alzheimer’s, ADD, Leukaemia, cancer and so on – for the injections AND the evolving solutions.

Defining the objective function coefficient is important. Should it be “reduction in red blood cells” or “shredding of endothelial cells” or “destruction of ova” or, probably better – each in turn against each toxic/poisonous/shredding effect.

Cause and effect for, the lipids, the nanoparticles, the modified mRNA instructions, the PEG, the monkey DNA segments, the e-coli and frame shifting, spider webs and anything else shown in a matrix against each organ – then against the medications for existing conditions that were suffered before C19.

Maybe a “heat map” and then some system that assigns numbers that quantify severity.

Next would be the evolving solutions – after of course describing the mechanism of action and time sensitivity (who so long!!!) AND their interactions with, not just the spike venom produced by the body, but also against pre-C19 existing conditions.

Talk about 3D chess! This would be a three-dimensional correlation “box” (volatility surface for you option traders out there) with the dimensions of injections component x vital organ x treatment for each type of injury!

Probably medically and scientifically invalid?

Speaking of optimization anyone heard of any research into molecular biology of the mechanisms of action of each of these?

I am guessing that C20-H50-B-Cl-I-N3-O6-S looks promising!

Here are a couple more promising solutions to take into account.

Friday Hope: Degrading the Spike Protein: Neanthes japonica (Izuka) (substack.com)

(For you Flash Gordon fans “Not the bore worm!”

And this:

Frontiers | Body Localization of ACE-2: On the Trail of the Keyhole of SARS-CoV-2 (frontiersin.org)

Which has this at the end:

A preclinical model of Vero-E6 cells, infected with SARS-CoV-2, isolated from a nasopharyngeal sample of COVID-19 patient, demonstrated the efficacy of human recombinant soluble ACE2 (hrsACE2) in inhibiting viral replication in a dose-dependent manner.

Such activity was also confirmed in human capillary organoids cultures and in kidney organoids cultures generated from human embryonic stem cells (331). In addition, the soluble ACE2 form seems to be also involved in blocking SARS-CoV-2 replication and in immune response against the virus, in concert with Fc portion of immunoglobulin (331).

The administration of rhACE2 also seems to induce a reduction of IL-6 levels in severe COVID-19 patients (333). “

Those organoids were probably grown with gene editing technology such as CRISPR.

Onwards!

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