Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture

Technical paper!

From here:

Hydroxychloroquine blocks SARS-CoV-2 entry into the endocytic pathway in mammalian cell culture | Communications Biology (nature.com)

https://www.nature.com/articles/s42003-022-03841-8#Sec2

and reported here:

Second looks: Peer-reviewed research questions mask study, finds hydroxychloroquine benefit | Just The News

https://justthenews.com/politics-policy/coronavirus/misinformation-peer-reviewed-research-questions-mask-study-finds

Properly qualified specialists (not me!) can discuss.

I latched on to these two statements:

“HCQ had the greatest effect on viral inhibition with almost a 90% reduction in SARS2-PV luciferase activity (Fig. 1b).”

and

“In Vero E6 cells, a cell line that endogenously expresses ACE2 receptor and robustly facilitates SARS-CoV-2 viral entry50, HCQ, tetracaine, and propofol all significantly decreased viral entry (Fig. 1c). HCQ again showed the strongest effect decreasing viral entry by ~92%.”

In vitro, not in vivo studies, but still, has to be more accurate than using 8 white mice right?