Merck collaborates with Moderna to produce improved treatment for melanoma – Phase 3 clinical trial for individually tailored mRNA (with psi- Ψ ?) injection post-surgery underway
The incidence of all sorts of cancers post the experimental C19 modified mRNA injections is attracting a lot of attention. Around one in 16-20 cancers are melanomas.
First some (cursory) US context:
From here:
Epidemiology of Melanoma - PMC (nih.gov)
“According to the latest SEER data, melanoma is the fifth most common cancer diagnosis in the US (excluding nonmelanoma skin cancers), with 106,000 estimated new cases in 2021, which represents 5.6% of all cancer diagnoses.”
From here:
Melanoma: Statistics | Cancer.Net
“In 2023, an estimated 97,610 adults (58,120 men and 39,490 women) in the United States will be diagnosed with invasive melanoma of the skin. Worldwide, an estimated 324,635 people were diagnosed with melanoma in 2020.”
“It is estimated that 7,990 deaths (5,420 men and 2,570 women) from melanoma will occur in the United States in 2023.”
So, around 8,000 deaths from around 100,000 cases of melanoma,
One treatment is pembrolizumab – which is a Humanized antibody used in cancer immunotherapy.
(Side note: I wonder what work was done on the incidence of melanoma post C19 mRNA injections or the “stalk binding” of cancer fighting IgG1 antibodies with cancer enabling IgG4 antibodies that may be a side effect of the modified mRNA in those injections?)
From here:
Keytruda (Pembrolizumab): 8 Answers Inc. Cost, Side Effects, and Success Rate (mytherapyapp.com)
“The price of Keytruda will vary greatly depending on location and insurance coverage. However, patients who are paying out-of-pocket can expect to pay around $12,500 per month, or $150,000 per year.”
Yikes!!! Okay, moving on to the collaboration between Merck & Co., Inc and Moderna. (Merck trades as Merck Sharp & Dohme outside the US.
Back to the Phase 3 clinical trial.
From here:
And here:
Using these methods:
“We did an open-label, randomised, phase 2b, adjuvant study of mRNA-4157 plus pembrolizumab versus pembrolizumab monotherapy in patients, enrolled from sites in the USA and Australia, with completely resected high-risk cutaneous melanoma”.
We have these findings:
“From July 18, 2019, to Sept 30, 2021, 157 patients were assigned to mRNA-4157 plus pembrolizumab combination therapy (n=107) or pembrolizumab monotherapy (n=50); median follow-up was 23 months and 24 months, respectively. “
"Recurrence-free survival was longer with combination versus monotherapy (hazard ratio [HR] for recurrence or death, 0·561 [95% CI 0·309–1·017]; two-sided p=0·053), with lower recurrence or death event rate (24 [22%] of 107 vs 20 [40%] of 50); 18-month recurrence-free survival was 79% (95% CI 69·0–85·6) versus 62% (46·9–74·3). “
Looks like a lowering of death rate from 40% to 22% (over 18 months?) with a survival rate improvement from 62% to 79%. Note the data for 8,000 deaths from 106,000 cases per annum above). Must be tough being in the placebo! And also, this “hazard ratio [HR] for recurrence or death, 0·561 [95% CI 0·309–1·017”. An HR somewhere between zero and 209?!?
Moving on…
“Most treatment-related adverse events were grade 1–2. Grade ≥3 treatment-related adverse events occurred in 25% of patients in the combination group and 18% of patients in the monotherapy group, with no mRNA-4157-related grade 4–5 events. Immune-mediated adverse event frequency was similar for the combination (37 [36%]) and monotherapy (18 [36%]) groups.”
Hmmm. A quarter of the mRNA plus pembrolizumab v 18% for just the pembrolizumab for suffered Grade ≥3 treatment – which presumably means “severe” life altering adverse events – but no serious life threatening events for the mRNA treatment.
I wonder how thorough the medical checks were – just a comparison between the two arms – that is were only know side effects investigated that occurred in the pembrolizumab arm of the study and no others? Were known side effects from the C19 modified mRNA injections looked for?
Ok, here’s a piece from the UK’s Daily Express calling this a significant medical breakthrough that has excited melanoma sufferers.
Revolutionary skin cancer vaccine offers hope of cure for British patients | Express.co.uk
““With this therapy, what you’re doing is dealing with the theoretical risk that the cancer could recur.”
“So there’s nothing to see on scans, but if there are some cells that have escaped that are below the detection of imaging ... what we’re trying to do is, on a patient-by-patient basis, give treatment to eradicate any of those rogue cells that might be sitting about.”
Fighting an invisible enemy! Must be hard to spot if you are winning or just lucky r simply making shirt up! The clinical trial is focussed on outcomes. I sure wish “authority would stand this sort of work against other treatments like IVM, nicotine patches and Fenbendazole so that we could all thank them for doing a great job, not motivated by money,
“Harnessing the same technology used to defeat the Covid pandemic, the mRNA jab is custom-built in a matter of weeks and given after surgery to stop the disease returning. Experts hailed it as the latest promising weapon in “a golden age of cancer research”.
Ack! That statement blows the credibility of the reporter right out of the water!
“These things are hugely technical and finely generated for the patient. The patients are really excited about them.”
“Known as mRNA-4157 (V940), the jab uses genetic material known as messenger RNA.
The injected mRNA guides some of the body’s cells to make harmless versions of markers that appear on the cancer cells, stimulating an immune response. This should help the immune system recognise and fight the disease in future.”
“Should”.
“Those who took it alongside the immunotherapy drug Keytruda were almost half (49 percent) as likely to die or have their cancer come back within three years than those given only Keytruda.”
Note the spin. The clinical trail reported this “Looks like a lowering of death rate from 40% to 22% (over 18 months?) with a survival rate improvement from 62% to 79%.”
See if you can get a 50% improvement in fatalities from that!
“It is now being tested in a global phase three study led by University College London Hospitals NHS Foundation Trust.
Researchers are aiming to recruit 1,100 patients worldwide, including 60-70 across eight UK centres in cities such as London, Manchester, Edinburgh and Leeds.”
No studies of Fenbendazole, Ivermectin or nicotine allowed! Perhaps we are entering the “cancer treatment wars” where the damages caused by mRNA experiments are being treated with mRNA experiments.
Watch for some news from Pfizer now it has done this:
Pfizer to buy oncology-focused biotech Seagen for $43bn (ft.com)
“Pfizer has agreed to acquire oncology-focused biotech Seagen for a total enterprise value of $43bn as the US pharmaceutical company refills its drugs pipeline amid a sharp fall in sales of its Covid-19 products.”
Two wrongs don’t make a right!
As a layman, it seems that there are serious holistic, educational gaps in the employees of big pharma.
Onwards!!!
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I wouldn’t let Pfizer put anything in my body. False data, false trials, big costs, no thanks.
And so, what started out as a therapeutic has become a vaccine, even an individually tailored vaccine. Didn’t it used to be that a vaccine was something that prevented it happening in the first place…or maybe my cynicism is getting ahead of me…or maybe Pharma is even more cynical than that.