Pseudouridine – wtf is it and what does it do – background notes – any similarity of the symbol for pseudo uridine Ψ, to a devil’s trident is purely coincidental (so is Luciferase!)
Bottom line? Pseudo uridine looks like a marker for cancer not a cause, maybe spike protein proliferation in lymph nodes point to a different type of harm.
This is a rabbit hole that requires navigational aids, so here are some. Skip these if you are easily bored!
Pseudo = not genuine; spurious or sham:
Uridine = a compound formed by partial hydrolysis of RNA. It is a nucleoside containing uracil linked to ribose.
RNA = Ribonucleic acid = a polymeric molecule either by performing a biological function itself (Non-coding RNA) or by forming a template for production of proteins (messenger RNA = mRNA (as opposed to modRNA that modifies RNA).
Polymers range from synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function. Polymers, both natural and synthetic, are created via polymerization of many small molecules, known as monomers.
Nucleoside = consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose)
Uracil = is one of the four nucleobases in the nucleic acid RNA. The others are adenine (A), cytosine (C), and guanine (G). In RNA, uracil binds to adenine via two hydrogen bonds. In DNA, the uracil nucleobase is replaced by thymine (T). Uracil is a demethylated form of thymine.
Ribose = The naturally-occurring form, d-ribose, is a component of the ribonucleotides from which RNA is built, and so this compound is necessary for coding, decoding, regulation and expression of genes.
Not referenced in the below but a plasmid = a genetic structure in a cell that can replicate independently of the chromosomes, typically a small circular DNA strand in the cytoplasm of a bacterium or protozoan. Plasmids are much used in the laboratory manipulation of genes.
LNP’s = Lipid Nanoparticles have been recognized as a novel pharmaceutical drug delivery system and are spherical vesicles composed on ionizable lipids, which are positively charges at low pH. They have an outer shell of lipid molecules with the ability to encapsulate and transport complex active ingredients (such as mRNA, RNA, siRNA, or DNA-based APIs)) to target cells in the human body.
That’s enough of that!
Ok, so pseudo uridine is used in C19 mRNA injections. Here is why:
From April 6, 2020
“..we show that synthetic mRNA switches containing N1-methylpseudouridine (m1Ψ) as a substitution of uridine substantially out-performed all other modified bases studied, exhibiting enhanced microRNA and protein sensitivity, better cell-type separation ability, and comparably low immune stimulation.
We found that the observed phenomena stem from the high protein expression from m1Ψ containing mRNA and efficient translational repression in the presence of target microRNAs or proteins. In addition, synthetic gene circuits with m1Ψ significantly improve performance in cells.”
The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines - PMC (nih.gov)
From 4 November 2021 – almost a year after launch of C19 mRNA injections:
“the clinical trial efficacy results of the Curevac mRNA vaccine (CVnCoV) suggested that the delivery system was not the only key to the success.
CVnCoV consisted of an unmodified mRNA (encoding the same spike protein as Moderna and Pfizer-BioNTech’s mRNA vaccines) and was formulated with the same LNP as Pfizer-BioNTech’s vaccine (Acuitas ALC-0315). However, its efficacy was only 48%.
This striking difference in efficacy could be attributed to the presence of a critical RNA modification (N1-methyl-pseudouridine) in the Pfizer-BioNTech and Moderna’s mRNA vaccines (but not in CVnCoV). “
Ok, we know that the efficacy claimed by Pfizer/BioNTech and Moderna was BS and that their manufacturing scale-up of clinical trial substances was completely different and contaminated because of crap quality control (monkey DNA and bacteria contaminants), but the “speed of science” lies showed 90-95% efficacy for injections using pseudo uridine v as around half (maybe a truthful half compared to a BS 95%).
Okay, so use pseudo uridine was the winning tactic.
What were the known risks of pseudo uridine? From April 12, 2021 (four months after roll-out)
The Role of Pseudouridine in Malignant Tumors (bocsci.com)
“Pseudouridine is the final product of tRNA degradation. When tRNA is degraded, pseudouridine can no longer be reused and is excreted in the urine as a complete molecule. (tRNA = transfer RNA).
Studies have shown that patients with malignant tumors such as thyroid cancer, nasopharyngeal cancer, lung cancer, breast cancer, liver cancer, gastric cancer, esophageal cancer, and lymphocytic leukemia often have a large amount of modified nucleosides, especially pseudouridine, in blood and urine.
Therefore, pseudouridine can be used as a tumor marker for the diagnosis, condition and efficacy monitoring and prognosis judgment of a variety of malignant diseases.”
If I am reading that right, pseudouridine is not necessarily causing cancer, but it is “often” present in blood and urine, indicating the presence of cancers.
“The high performance liquid chromatography method for the determination of pseudouridine has the advantages of sensitivity, accuracy, speed, and small sample consumption, so it has become the most commonly used method for the detection of pseudouridine.”
Moving on!
From here:
Pseudouridine, mRNA Vaccines & Spike Protein Persistence (substack.com)
“Two important questions spring to mind:
Can mRNA molecules be too stable and cause too much protein synthesis?
Beyond mRNA stability, are there any cellular consequences to swapping in pseudouridine for uridine?
The answer to both questions is, “Yes.”
(The spike protein mRNA in vaccines is also protected by lipid nanoparticles—small bubbles of fat.)
How long after vaccination do these pseudouridine-containing mRNA molecules stick around? This was something measured in a recent study comparing the immune responses to vaccination vs. SARS-CoV-2 infection.
To measure this, researchers biopsied the lymph nodes of people who had received two doses of the Pfizer vaccine. They measured the presence of vaccine mRNA in the lymph nodes as early as 7 days and as late as 60 days after the second vaccine dose.”
Does pseudouridine have consequences beyond mRNA stability?
In addition to the stabilizing effect that the use of pseudouridine had for the mRNA vaccines, there are other consequences. The biology gets complicated, so I’ll simply say that it can cause issues for the molecular machines that scan mRNA molecules and translate this genetic information into a protein. These are called ribosomes.”
“Immune imprinting, breadth of variant recognition and germinal center response in human SARS-CoV-2 infection and vaccination Cell. Published:January 24, 2022DOI:https://doi.org/10.1016/j.cell.2022.01.018
Highlights (per the journal)
Vaccination confers broader IgG binding of variant RBDs than SARS-CoV-2 infection
Imprinting from initial antigen exposures alters IgG responses to viral variants
Histology of mRNA vaccinee lymph nodes shows abundant germinal centers
Vaccine spike antigen and mRNA persist for weeks in lymph node germinal centers
One very real hypothesis is that the substitution of pseudouridine for uridine to avoid the immune response is working so well that the mRNA is completely evading the normal clearance/degradation pathways. Hence, mRNA that is not being incorporated into cells at the injection site, is migrating to the lymph nodes (and throughout the body as the non-clinical Pfizer data suggest?) and continuing to express protein there.”
Onwards!
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The dying "Enlightened Tradition" that rejected symbols and the metaphysical is self-evidently reaping what it sowed. Those who wilfully ignore the implied warnings, the symbolism of manifest self-betraying evil appear more likely to perish?
Highlighted beautifully elsewhere: https://naomiwolf.substack.com/p/energies-continued
"We live in a mysterious world. Mechanics do not explain the totality of it.
We are held together human to human, by energies of love that are as strong as death. Our lives are held in the palm of the Divine, like leaves on the surface of water.
Who knows all that is around us and that animates us?"
So we are in a situation. Frankenstein has gotten together with the rest of the world's mad scientists. They haveenriched themselves beyond all recognition.
They have decided that they know enough to do whatever they please.