Some notes on stem cell research and developments with possible applications to C19

I cross posted this article a few days ago:

Friday Hope: Stem Cells: Evidence for Successful Treatment in Acute COVID (substack.com)

“Reviewing all the evidence we have seen regarding the Spike Protein over the years, one truth is very apparent: The Spike Protein has the ability to either kill or permanently alter cells. Therefore, it is only logical that replacing dead or altered cells with healthy, new cells should help the body recover from COVID and Spike Protein-related pathologies. Indeed, this appears to be the case.”

Pursuing this further, I ran across this article, Here is a link to a systematic review of stem cell research from 2021 - The database search for this systematic review was conducted in March 2021.

Stem cell-based therapy for COVID-19 and ARDS: a systematic review | npj Regenerative Medicine (nature.com)

Here’s a few extracts:

“A significant number of cell-based therapies have been through clinical investigation. In this study, we performed a systematic review of clinical studies investigating different types of stem cells as treatments for COVID-19 and ARDS to evaluate the safety and potential efficacy of cell therapy.”

Mesenchymal stem cells (MSCs) Mesenchymal stem cell - Wikipedia “Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue).”

Stem Cells: Ask Health Professionals (msn.com)

“In multicellular organisms, stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. They are the earliest type of cell in a cell lineage. They are found in both embryonic and adult organisms,”

From babies or adults…

Back to the systemic review, here’s all the different types od studies reviewed.

“Intervention characteristics

Among the 29 selected clinical articles, eleven types of umbilical cord MSCs were analyzed. The cell types investigated in the studies comprised

(1) human umbilical cord MSCs

(2) cardiosphere-derived MSCs

(3) human bone marrow MSCs

(4) extracellular vesicles derived from BM-MSCs (BM – Bone marrow)

(5) autologous peripheral blood-derived mononuclear cells (PBMCs)

(6) human adipose tissue-derived MSCs

(7) allogeneic bone marrow-derived multipotent adult progenitor cells (MAPC) expanded ex vivo

(8) ACE2-MSCs

(9) human menstrual blood-derived MSCs

(10) immunity‐and matrix-regulatory cells (IMRCs)

(11) MSCs derived from perinatal tissues

Umbilical chords, perinatal lots of baby parts needed? Refresh - Mesenchymal stem cells = MSC;s

“Eighteen studies assessed symptoms at admission and clinical status after cell therapy, and all of them reported clinical improvement.”

Results of other criteria, a lot of them, reported success rates of 80% or so. Lots more detail I the review.

“In a concept study, 13 severe COVID-19 patients requiring mechanical ventilation and receiving the standard care treatment were infused with adipose tissue-derived MSCs.

Within 5 days of the treatment nine (70%) patients showed clinical improvements with significant reductions in CRP, lactate dehydrogenase (LDH), D-dimer, and ferritin.

Moreover, five patients demonstrated improvements concerning B-lymphocyte alongside better CD4+ and CD8+ counts, and ultimately, after the MSCs infusion seven patients were extubated within a median time of 7 days.”

No serious or severe adverse events reported ,but there was this for mortality:

“Mortality

There were no reported deaths directly linked to stem cell administration.

Death was observed in 17 studies, and a total of 79 patients died out of 472, including placebo and patients who received MSCs.

It was reported that 47 (14%) deaths occurred among 330 patients receiving MSC infusions, while the placebo groups had 32 (23%) deaths out of 142 patients. Five studies described deaths caused by complications of COVID-19.

I cannot find any follow-ups or whether the baby donors and menses were screened for prior C19 infection or timing/frequency of either mRNA or viral vector injections. Probably the Sinovac injection in most of the studies? Neither could I spot ay follow-ups over time or against emerging variants.

I also looked at the abstract of this paper co-authored by the “guru” of gene editing, organoids etc, George Church, from April 2022:

Orthogonally induced differentiation of stem cells for the programmatic patterning of vascularized organoids and bioprinted tissues - PubMed (nih.gov)

Just the abstract for non-subscribers to PubMed, but this part of the abstract:

“Specifically, we used such orthogonally induced differentiation to generate endothelial cells and neurons from hiPSCs in a one-pot system containing either neural or endothelial stem-cell-specifying media, and to produce vascularized and patterned cortical organoids within days by aggregating inducible-transcription-factor and wild-type hiPSCs into randomly pooled or multicore-shell embryoid bodies. “”.

hiPSCs = human induced pluripotent stem cells , it goes on:

“Moreover, by leveraging multimaterial bioprinting of hiPSC inks without extracellular matrix, we generated patterned neural tissues with layered regions composed of neural stem cells, endothelium and neurons. Orthogonally induced differentiation of stem cells may facilitate the fabrication of engineered tissues for biomedical applications.”

I did not spot any detail on the source of the babies and menses. Abortion clinics or volunteers?

Anyway, the phenomenon seems to be gaining traction. Check this out from Switzerland:

Swiss Medica3 - Stem Cell Therapy Expected Results (startstemcells.com)

Not suitable for everyone but here is a list of possible “cures”:

They all look kind of “C19’y”! My “spidey senses” are wondering if this is part of a one-two punch to create an mRNA problem and then cure it with stem cells, organoids and gene editing!

Here’s a UK site:

UK's Leading Umbilical Cord Blood Stem Cell Bank    (cells4life.com)

Which has this banner:

And a link to this:

Umbilical cord mesenchymal stem cells for COVID‐19 acute respiratory distress syndrome: A double‐blind, phase 1/2a, randomized controlled trial - Lanzoni - 2021 - STEM CELLS Translational Medicine - Wiley Online Library

“This double blind randomized controlled trial in 24 subjects demonstrated fewer serious adverse events in the UC-MSC treatment group compared with the control group.”

“UC-MSC treatment was associated with a significant decrease in a set of inflammatory cytokines involved in the COVID-19 “cytokine storm.”

UC-MSC treatment was associated with significantly improved patient survival and time to recovery.

The observed findings strongly support further investigation in a larger trial designed to estimate and establish efficacy.”

So, more research needed, but full steam ahead offering the “product”.

Onwards!

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