Some notes on immunoglobulins – especially IgE – no conclusions - what analysis done during clinical trials, and after, of C19 mRNA and viral vector injections impact on Ig's G, M, A, D and E?
First some definitions:
immunoglobulins (plural noun) - any of a class of proteins present in the serum and cells of the immune system, which function as antibodies:
antibodies (plural noun) - a blood protein produced in response to and counteracting a specific antigen. Antibodies combine chemically with substances which the body recognizes as alien, such as bacteria, viruses, and foreign substances in the blood.
anti·gen - a toxin or other foreign substance which induces an immune response in the body, especially the production of antibodies.
Ok, so far so good. From here: Immune system - IgA, IgG, IgM | Britannica
“All immunoglobulins that have the same basic kinds of constant domains in their H chains are said to belong to the same class.
There are five main classes—IgG, IgM, IgA, IgD, and IgE—some of which include a number of distinct subclasses. Each class has its own properties and functions determined by the structural variations of the H chains.
In addition, there are two basic kinds of L chains, called lambda and kappa chains, either of which can be associated with any of the H chain classes, thereby increasing still further the enormous diversity of immunoglobulins.”
Okay, a little deeper, not drowning yet! There are five main classes G, M, A, D and E.
Now, what do they do?
Immunoglobulins and Immunoglobulin Tests: Function and Clinical Uses (healthline.com)
“Immunoglobulins, also called antibodies, are molecules produced by white blood cells that help your body defend against infections and cancer. Their primary function is to bind to foreign cells like bacteria and viruses. This binding helps neutralize the foreign cell and signals to your white blood cells to destroy them.”
Essential! Each will have a function that prevents us from being riddled with diseases like cancer as well as infections.
Ok, now remember the discussions about immunoglobulin G and sub units 1,3 and 4 at the start of the year?
Plus lots since and this one from today:
(100) A possible explanation of Sweden's low excess mortality!! Mystery solved?? (aussie17.com)
Referencing this recent study:
Here’s what caught my inexpert eye.
“Levels of spike-specific IgG subclasses expressed as percentages of all spike-specific IgG antibodies
The percentages of spike-specific IgG4 were higher in the vaccinated groups than in the COVID-19 cohort groups.
The proportions of the spike-specific IgG4 subclass to the sum of all spike-specific IgG antibodies were between 1 and 3% in the CONV and HOSP groups, respectively.
In the vaccinated groups, we detected 16.6% of spike-specific IgG4 in the Vector/no INF group, whereas its values were as high as 41.5% and 45.7% in the mRNA → INF and mRNA/no INF groups, respectively (Fig. 5).”
“In our COVID-19 patients, the spike-specific IgG1 and IgG3 antibody subclasses were dominantly present on median 21 days post-infection. Several reports also showed that the dominant subclasses in COVID-19 patients were spike-specific IgG1 and IgG320.”
“ IgG3 appears early in viral infections” .. “The further class switch recombinations follow a one-way direction IgG3 → IgG1 → IgG2 → IgG4 subclasses21,22. We found that the pattern of spike-specific IgG subclasses was markedly different in mRNA-vaccinated individuals with or without prior SARS-CoV-2 infection.”
Okay, any further and a novice like me will be thinking that the mRNA shots eat IgG1 and 3, leaving IgG4 alone and maybe making it a significantly higher proportion of what’s left! I might go on to think that maybe heavy doses of IgG1 and 3 might win a war on restoring balance – which is why I am not an expert!
All that was about IgG. What about IgE and why did I bring this up?
Well, here’s an article about IgE from 28 July 2023 (my birthday, hence why I missed it!
“As alpha-gal syndrome (AGS), a tick-borne disease that triggers an allergic reaction to red meat, sees a steep rise in cases, eyebrows are being raised over a coincidental alignment with research funded by the Bill & Melinda Gates Foundation.
AGS, first reported in Virginia in 2008, has seen an alarming increase over the past few years. According to a recent press release from the U.S. Centers for Disease Control and Prevention (CDC), an estimated 450,000 people in the U.S. have tested positive for alpha-gal since 2010.
In 2021, the number of positive test results for AGS surged by 41.3% compared to 2017, and testing for alpha-gal peaked at 66,106 persons that year.”
“In June 2023, after Oxitec reported high efficacy in its tick experimentation, the Gates Foundation provided an additional $4.8 million in funding.”
You remember Oxitec?
Billions more released since then.
Ok, back to IgE, meat ant ticks article in American Faith, one more snippet:
“Fast forward to March 2023, and FFF Enterprises, a specialty vaccine distributor, announced it would start stocking the Gates-backed artesunate vaccine. Three months later, in June 2023, the CDC issued an alert about locally acquired malaria cases in Florida and Texas. Interestingly, the CDC, funded by the Gates Foundation, recommended rapid access to the artesunate vaccine.”
Now, what’s the beef (sic) with IgE?
From here:
The Meat of the Matter: Understanding and Managing Alpha-Gal Syndrome - PMC (nih.gov)
“Alpha-gal syndrome is an unconventional food allergy, characterized by IgE-mediated hypersensitivity responses to the glycan galactose-alpha-1,3-galactose (alpha-gal) and not to a food-protein.
In this review, we discuss how alpha-gal syndrome reframes our current conception of the mechanisms of pathogenesis of food allergy. The development of alpha-gal IgE is associated with tick bites though the possibility of other parasites promoting sensitization to alpha-gal remains. “
“Alpha-gal moieties are common in nature and present in non-primate mammals such as cows, pigs, and sheep. They are also present in various food products derived from those animals including dairy products, meat, and their innards.
Consumption of those food products may result in symptoms ranging from urticaria to potentially lethal anaphylaxis.1 Individuals suffering from AGS may also be exposed to alpha-gal through various pharmaceutical products that contain alpha-gal such as the cancer drug cetuximab.2”
Surfing to this:
“There are concerns of vaccine-induced allergies, but mostly about allergic responses to the adjuvant. We, however, found that repetitive exposure to SARS-CoV-2 spike, not Nucleocapsid (N) protein, can induce robust type 2 inflammation in the airway of mice, which is exacerbated by the presence of house dust mite allergens.
This type 2 inflammation is accompanied with elevated IgE and neutralizing antibody production. To further test whether spike glycosylation influences these responses, we compared the immunogenicity of insect cell expressed spike (in-S), mammalian cell expressed spike (m-S) and deglycosylated spike (dg-S).
With intranasal treatment, in-S induced high levels of anti-spike/S1 specific IgE, while m-S and dg-S induced detectable NAb titers as determined by pseudo-virus (PV) neutralization assays. “
But..
“.. our data suggests that vaccination with SARS-CoV-2 spike may induce antigen-specific allergic response, while immunization with the deglycosylated spike protein may help enhance protective immune responses.”
Deglycosolated? Ok, leave that to the experts – seems to suggest that there is a process improvement possible in the C19 injections? Maybe this paper is related:
Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine | PNAS
or this one:
N- and O-Glycosylation of the SARS-CoV-2 Spike Protein - PMC (nih.gov)
My eyes glazed over, three times!
Okay, moving onto here for some more context for the role of IgE in cancer formation in addition to allergies:
What Is Immunoglobulin E (IgE)? (verywellhealth.com)
“Cancer: The exact relationship between IgE levels and cancer is not well understood. Still, studies suggest that higher levels of IgE may correlate with a decreased risk of cancer. In contrast, low serum levels of IgE may be associated with higher cancer risk, particularly lymphomas, but the serum levels have yet to be defined.5”
I will end the notes with this piece:
“Data suggest that individuals with higher absolute eosinophil counts (AEC) have better outcomes of COVID-19 infection. It remains unknown if other molecules of the TH2 immune response, such as immunoglobulin (Ig) E, play a role.”
“Conclusions
These data raise the possibility that other molecules of the TH2 pathway may also be involved in COVID-19-asociated mortality. Larger studies are necessary to better define the relationship between IgE, AEC, and COVID-19 outcomes.”
Onwards
Please upgrade to paid, or donate a coffee (I drink a lot of coffee) - “God Bless You!” if you can’t or don’t want to contribute. Coffee donations here: https://ko-fi.com/peterhalligan Buying just one Ko-Fi a week for $3 is 50 bucks more than an annual $100 subscription!
Very useful. Thank you. I've only skimmed through it, will read more carefully later, but re. definition of antibodies - "a blood protein produced in response to and counteracting a SPECIFIC antigen" - that seems unlikely if there are only 5 classes of immunoglobulins, even with all their sub-classes, given the millions/trillions of toxins flying around. Also why use non-specific antibodies to test for a specific toxic protein/antigen rather than isolate that specific toxic protein directly from blood/tissues? Why beat around the bush when you know exactly what you're looking for, like the spike protein?
Every day, the emerging stories get more horrendous.